Description

n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Adenosine Phosphoramidite is a highly specialized, protected nucleoside phosphoramidite monomer essential for the solid-phase synthesis of oligonucleotides. This compound matters because it enables the precise and efficient incorporation of modified adenosine residues into synthetic DNA and RNA strands, a critical process for advanced life science research and therapeutic development. It is primarily needed by biotechnology and pharmaceutical companies engaged in the development of antisense oligonucleotides, siRNA, aptamers, and other nucleic acid-based therapeutics and diagnostics.

Application

• Oligonucleotide Synthesis: As a key building block (monomer) in automated solid-phase synthesizers for the production of custom DNA and RNA sequences.
• Therapeutic Nucleic Acid Development: For the research and manufacturing of antisense oligonucleotides, siRNA (small interfering RNA), and aptamers used in targeted therapies.
• Diagnostic Probe Manufacture: In the creation of labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and microarray technologies.
• Basic Biochemical Research: Used in academic and industrial labs to study nucleic acid structure, function, and protein interactions with site-specifically modified oligonucleotides.
• Synthesis of Modified Nucleosides: Serving as a critical intermediate for further chemical modification to create novel nucleoside analogs.

Basic Information

Item	Detail
Product Name	n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Adenosine Phosphoramidite
CAS No.	196408-66-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(R)-1-(2-fluorophenyl)-4-methoxypiperidin-4-yl]adenosine 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-FPMP-5'-O-DMT-Adenosine-3'-CE Phosphoramidite; 2'-O-(1-(2-Fluorophenyl)-4-methoxypiperidin-4-yl)-5'-O-DMT Adenosine CE Phosphoramidite; FPMP-protected Adenosine Phosphoramidite; DMT-FPMP-Adenosine-CE Phosphoramidite; n-Blocked Adenosine Phosphoramidite Derivative
EINECS	Contact for details

Quality Control

Our n-Blocked-5'-o-Dmt-2'-o-Fpmp Ced Adenosine Phosphoramidite is manufactured under strict quality control protocols suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, moisture content, and performance in coupling efficiency tests is provided with every shipment to ensure batch-to-batch consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or higher temperatures will lead to decomposition and reduced coupling efficiency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Coupling Efficiency Test	≥ 98.5% step-wise yield

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.