Description

α-Methyl-4-(Isobutyl) Benzyl Penicillin Sodium is a semi-synthetic penicillin derivative, specifically a penicillinase-resistant penicillin sodium salt. This compound is valued for its enhanced stability against β-lactamase enzymes, making it a critical intermediate in the research and development of advanced antibiotic formulations. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in antimicrobial drug discovery and synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel penicillin-based antibiotics and prodrugs.
• Antimicrobial Research: Used as a reference standard or active component in microbiological studies targeting resistant bacterial strains.
• Fine Chemical Synthesis: Serves as a specialized intermediate for constructing complex molecules with β-lactam cores in organic chemistry.
• Analytical Standard: Employed as a high-purity standard for method development and quality control in HPLC, LC-MS, and other analytical techniques.
• Biochemical Studies: Utilized in research investigating the structure-activity relationships (SAR) and mechanisms of β-lactam antibiotics.

Basic Information

Product Name	α-Methyl-4-(Isobutyl) Benzyl Penicillin Sodium
CAS No.	196309-77-0
Molecular Formula	C22H25N2NaO5S
Molecular Weight	452.50 g/mol
Synonyms	4-Isobutyl-α-methylbenzylpenicillin Sodium Salt; Sodium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[(2R)-2-[[4-(2-methylpropyl)phenyl]acetyl]amino]-2-phenylacetamido]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Penicillin SA-178; Isobutylbenzyl Penicillin Sodium Derivative; α-Methyl-4-isobutylbenzyl Penicillin Sodium
EINECS	Contact for details

Quality Control

Our α-Methyl-4-(Isobutyl) Benzyl Penicillin Sodium is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
pH (10% solution)	5.5 - 7.5
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.