Description

2,4-Difluoro-3-Hydroxybenzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective functionalization and incorporation into complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and electron-transport materials.
• Chemical Research: A versatile starting material for academic and industrial research in fluorination chemistry and heterocycle formation.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring specific fluorinated motifs.

Basic Information

Product Name	2,4-Difluoro-3-Hydroxybenzoic Acid Methyl Ester
CAS No.	194804-80-3
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	Methyl 2,4-difluoro-3-hydroxybenzoate; 3-Hydroxy-2,4-difluorobenzoic Acid Methyl Ester; Benzoic acid, 2,4-difluoro-3-hydroxy-, methyl ester; Methyl 3-hydroxy-2,4-difluorobenzoate; 2,4-Difluoro-3-hydroxybenzoic acid methyl ester; 194804-80-3; Methyl 2,4-difluoro-3-hydroxybenzoate
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-3-Hydroxybenzoic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.