Description

Oritavancin Diphosphate is a semi-synthetic lipoglycopeptide antibiotic derivative. This compound is a critical active pharmaceutical ingredient (API) valued for its potent and prolonged bactericidal activity against Gram-positive pathogens. It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of advanced antibiotic formulations targeting serious skin infections and other resistant bacterial diseases.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of injectable antibiotic formulations.
• Research and development of novel antimicrobial agents and combination therapies.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Biochemical research focusing on the mechanism of action against drug-resistant bacteria like MRSA.
• Pre-clinical and clinical studies for evaluating pharmacokinetics and efficacy.

Basic Information

Product Name	Oritavancin Diphosphate
CAS No.	192564-14-0
Molecular Formula	C₈₆H₁₀₀Cl₃N₁₀O₂₈P₂
Molecular Weight	1900.10 g/mol (for free base calculation; diphosphate salt form)
Synonyms	LY333328 diphosphate; Oritavancin phosphate; N''-((4S)-4-[(4R)-4-[(4S,5R)-5-[(2R,3S,4R,5R,6R)-5-Amino-6-methyl-4-[(2R,3R,4R,5R,6S)-3-amino-6-[(2R,3S,6R)-3-[(2S)-2-aminopropanamido]-6-methyloxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxy-3-(methylamino)oxan-2-yl]oxy-4-(carbamoylmethyl)-4,5-dihydro-2H-furan-2-yl]-3-(3,5-dichloro-4-hydroxyphenyl)-2-oxo-1,3-oxazolidin-5-yl]-3-(4-chlorophenyl)-2-oxo-1,3-oxazolidin-4-yl]-3-(3,5-dichloro-4-hydroxyphenyl)propanimidamide diphosphate
EINECS	Contact for details

Quality Control

Our Oritavancin Diphosphate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and microbiological tests is supplied with every shipment to guarantee compliance with your stringent requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 0.50 EU/mg
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/ USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.