Description

4-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride is a high-value, multi-functional aromatic acid chloride intermediate. Its core value proposition lies in its unique trifluoromethyl and fluorine substituents, which are critical for modifying the physicochemical properties of target molecules, enhancing metabolic stability, lipophilicity, and bioavailability. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical sectors, where it serves as a key building block for synthesizing advanced active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective drug discovery programs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups contribute to enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a key intermediate in the manufacture of fluorinated compounds for electronic display and lighting applications.
• Polymer Modification Agent: Employed to introduce fluorinated aromatic units into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences industry.
• Research & Development: Used in academic and industrial labs for exploring new chemical entities and reaction methodologies in fluoroorganic chemistry.

Basic Information

Product Name	4-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride
CAS No.	189807-21-4
Molecular Formula	C8H3ClF4O
Molecular Weight	226.56 g/mol
Synonyms	4-Fluoro-2-(trifluoromethyl)benzoyl chloride; 2-(Trifluoromethyl)-4-fluorobenzoyl chloride; 4-Fluoro-alpha,alpha,α-trifluoro-o-toluoyl chloride; 189807-21-4; Benzoyl chloride, 4-fluoro-2-(trifluoromethyl)-; 4-Fluoro-2-trifluoromethylbenzoyl chloride; o-Trifluoromethyl-p-fluorobenzoyl chloride
EINECS	Contact for details

Quality Control

Our production of 4-Fluoro-2-(Trifluoromethyl)Benzoyl Chloride adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.