Description

3,4-Difluoro-2-Hydroxybenzoic Acid is a fluorinated aromatic carboxylic acid derivative that serves as a versatile and high-value synthetic building block. Its molecular structure, featuring both hydroxyl and carboxylic acid functional groups on a difluorinated benzene ring, makes it a critical intermediate for creating advanced materials and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials, where the fluorine atoms can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides, leveraging the fluorine substitution to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronic devices due to its ability to modify electronic properties and molecular alignment.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties for high-performance coatings and engineering plastics.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry, synthesizing novel heterocycles, and developing catalytic methodologies.
• Complex Ligand Synthesis: Utilized in the preparation of specialized chelating agents and ligands for metal-organic frameworks (MOFs) and catalysis, where the hydroxyl and carboxyl groups provide coordination sites.

Basic Information

Product Name	3,4-Difluoro-2-Hydroxybenzoic Acid
CAS No.	189283-51-0
Molecular Formula	C7H4F2O3
Molecular Weight	174.10 g/mol
Synonyms	2-Hydroxy-3,4-difluorobenzoic Acid; 3,4-Difluoro-2-hydroxybenzoic acid; 3,4-Difluorosalicylic Acid; 2-Hydroxy-3,4-difluorobenzoic acid; Benzoic acid, 2-hydroxy-3,4-difluoro-; 189283-51-0; 3,4-Difluoro-2-hydroxy-benzoic acid
EINECS	Contact for details

Quality Control

Every batch of 3,4-Difluoro-2-Hydroxybenzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, and custom specifications can be developed to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.