Description

1-(3,4-Difluorophenyl)Cyclopropanecarboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring substituted with a difluorophenyl moiety. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry and bioactivity. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel APIs, especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the difluorophenyl group enhances biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals due to its rigid cyclopropane structure.
• Chemical Reference Standard: Supplied as a certified standard for analytical method development and quality control in regulatory submissions.

Basic Information

Product Name	1-(3,4-Difluorophenyl)Cyclopropanecarboxylic Acid
CAS No.	186347-67-1
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	1-(3,4-Difluorophenyl)cyclopropanecarboxylic acid; 1-(3,4-Difluorophenyl)cyclopropanecarboxylate; 3,4-Difluoro-1-cyclopropanecarboxylic acid benzene; Cyclopropanecarboxylic acid, 1-(3,4-difluorophenyl)-; 186347-67-1; 1-(3,4-Difluorophenyl)cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(3,4-Difluorophenyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.