Description

3,5-Bis(Trifluoromethyl)Hydrocinnamic Acid is a high-value fluorinated aromatic building block characterized by its unique trifluoromethyl-substituted phenyl ring. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the introduction of fluorine atoms is used to fine-tune biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, kinase inhibitors, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups enhance product efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify surface properties and electronic characteristics.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Hydrocinnamic Acid
CAS No.	181772-16-7
Molecular Formula	C11H8F6O2
Molecular Weight	286.17 g/mol
Synonyms	3-[3,5-Bis(trifluoromethyl)phenyl]propanoic Acid; 3,5-Bis(trifluoromethyl)benzenepropanoic Acid; Hydrocinnamic Acid, 3,5-bis(trifluoromethyl)-; 3,5-Bis(trifluoromethyl)phenylpropionic Acid; α,α,α,α',α',α'-Hexafluoro-3,5-xylene-β-propionic Acid
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Hydrocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.