Description

(1S,3S)-Solifenacin Hydrochloride is a high-purity, single-enantiomer active pharmaceutical ingredient (API) used in the synthesis of advanced therapeutic agents. This compound is the pharmacologically active isomer of solifenacin, offering superior specificity and efficacy for targeted drug development. It is essential for pharmaceutical manufacturers and research institutions focused on developing and producing innovative urological and antimuscarinic medications. Our product is supplied under stringent quality control to meet the exacting standards of the global pharmaceutical industry.

Application

• Primary API for the manufacture of solifenacin succinate, a leading medication for overactive bladder (OAB) syndrome.
• Pharmaceutical Intermediates in the synthesis of enantiomerically pure antimuscarinic drugs.
• Research & Development of new therapeutic agents targeting muscarinic acetylcholine receptors.
• Reference Standard for analytical method development and quality control in pharmaceutical laboratories.
• Process Chemistry for scaling up production of chiral pharmaceutical compounds.
• Formulation Development for creating controlled-release and combination drug products.

Basic Information

Product Name	(1S,3S)-Solifenacin Hydrochloride
CAS No.	180468-38-6
Molecular Formula	C23H26N2O2 • HCl
Molecular Weight	410.93 g/mol
Synonyms	(3S)-1-Azabicyclo[2.2.2]oct-8-yl (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate hydrochloride; Solifenacin Hydrochloride (Isomer); YM-905 Hydrochloride; Vesicare® API Intermediate; (1S,3S)-YM-905 HCl; (S,S)-Solifenacin HCl; UNII-6H8V27K6A8
EINECS	Contact for details

Quality Control

Our (1S,3S)-Solifenacin Hydrochloride is manufactured under cGMP conditions to ensure the highest standards of purity and consistency. Each batch is subjected to comprehensive analytical testing, including HPLC for assay and impurity profiling, chiral purity analysis, and residual solvent testing. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with in-house specifications and supporting regulatory filings for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 99.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.5%
Related Substances (HPLC)	Total impurities ≤ 0.5% Any single impurity ≤ 0.1%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.