Description

Benzoyl Chloride, 4-Ethynyl-2-Fluoro- (9Ci) is a specialized aromatic acid chloride derivative, distinguished by the presence of both an ethynyl and a fluorine substituent on the benzoyl core. This unique molecular architecture makes it a high-value building block for advanced organic synthesis, particularly in the development of complex molecules with tailored electronic and steric properties. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those targeting kinase inhibition or requiring fluorine incorporation for metabolic stability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides where the ethynyl group enables "click chemistry" for modular assembly.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Acts as a versatile probe or linker for bioconjugation and labeling studies due to its reactive acid chloride and alkyne functionalities.
• Organic Synthesis Research: A valuable reagent in academic and industrial R&D for constructing complex aromatic and heterocyclic compounds via Friedel-Crafts acylation or amide coupling.
• Fluorine Chemistry: The fluorine atom provides a strategic handle for modulating lipophilicity and bioavailability in drug discovery programs.

Basic Information

Product Name	Benzoyl Chloride, 4-Ethynyl-2-Fluoro- (9Ci)
CAS No.	179232-31-6
Molecular Formula	C9H4ClFO
Molecular Weight	182.58 g/mol
Synonyms	4-Ethynyl-2-fluorobenzoyl chloride; 2-Fluoro-4-ethynylbenzoyl chloride; 4-Ethynyl-2-fluorobenzoic acid chloride; (4-Ethynyl-2-fluorophenyl)(chloro)methanone; 179232-31-6; 4-Ethynyl-2-fluoro-benzoic acid chloride; 2-Fluoro-4-ethynyl-benzoic acid chloride
EINECS	Contact for details

Quality Control

Our production of Benzoyl Chloride, 4-Ethynyl-2-Fluoro- adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.