Description

7-Tfa-Ap-7-Deaza-Da CAS NO 178420-75-2 is a high-purity, modified nucleoside analog used as a critical building block in oligonucleotide synthesis. This compound is essential for advanced research and development in nucleic acid chemistry, enabling the creation of probes and therapeutics with enhanced stability and specificity. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic research institutions focused on antisense technology, siRNA, and molecular diagnostics.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antisense & siRNA Therapeutics: Incorporation into therapeutic oligonucleotides to improve nuclease resistance and target binding affinity.
• Molecular Probes & Diagnostics: Used in the development of fluorescent probes and primers for PCR and sequencing applications.
• Structural Biology Studies: Employed to investigate nucleic acid structure, function, and protein-nucleic acid interactions.
• Medicinal Chemistry Research: Serves as a scaffold for developing novel nucleoside-based drug candidates.
• Bioconjugation: The reactive trifluoroacetyl (Tfa) protecting group allows for further functionalization and labeling.

Basic Information

Item	Detail
Product Name	7-Tfa-Ap-7-Deaza-Da
CAS No.	178420-75-2
Molecular Formula	C₁₇H₁₈F₃N₅O₆
Molecular Weight	445.35 g/mol
Synonyms	7-Deaza-2'-deoxyadenosine, N6-Trifluoroacetyl-7-deaza-2'-deoxyadenosine; 7-Deaza-2'-deoxyadenosine, 6-N-(trifluoroacetyl)-; 6-N-Trifluoroacetyl-7-deaza-2'-deoxyadenosine; 7-Deaza-dA-CE Phosphoramidite (protected precursor); N6-TFA-7-deaza-2'-deoxyadenosine; 7-Deaza-2'-deoxyadenosine derivative
EINECS	Contact for details

Quality Control

Every batch of 7-Tfa-Ap-7-Deaza-Da is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with high-purity standards suitable for pharmaceutical research and oligonucleotide synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.