Description

4-Amino-3-(Trifluoromethoxy)Benzoic Acid is a high-value trifluoromethoxy-substituted benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a trifluoromethoxy group, makes it an essential intermediate for creating compounds with enhanced biological activity and metabolic stability. This product is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating molecules with improved pharmacokinetic properties.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides where the trifluoromethoxy group can enhance activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Fluorinated Polymer Synthesis: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, and low surface energy properties.
• Chemical Biology & Proteomics: Utilized as a molecular probe or linker in biochemical research due to its reactive functional groups.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers for the production of complex, customer-specific molecules.

Basic Information

Product Name	4-Amino-3-(Trifluoromethoxy)Benzoic Acid
CAS No.	175278-22-5
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	3-(Trifluoromethoxy)-4-aminobenzoic Acid; 4-Amino-3-(trifluoromethoxy)benzoic acid; Benzoic acid, 4-amino-3-(trifluoromethoxy)-; 4-Amino-α,α,α-trifluoro-m-anisic Acid; 4-Amino-3-trifluoromethoxybenzoic Acid; 4-Amino-3-(trifluoromethoxy)benzoic acid (ACI); AKOS BRN-0769; ZINC000257019759
EINECS	Contact for details

Quality Control

Every batch of 4-Amino-3-(Trifluoromethoxy)Benzoic Acid undergoes rigorous analytical testing to ensure it meets stringent purity and identity specifications. Our quality assurance protocols are designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.