Description

3-Chloro-2,4,6-Trifluorobenzoic Acid is a high-value, multi-functional aromatic building block characterized by its unique halogen and fluorine substitution pattern. This compound is essential for introducing specific steric and electronic properties into target molecules, enabling the synthesis of advanced materials and active ingredients. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel compounds with enhanced biological activity and physical stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Serves as a critical precursor for novel herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity, metabolic stability, and binding affinity.
• Liquid Crystal & OLED Materials: Used in the synthesis of fluorinated aromatic cores for advanced electronic materials, enhancing thermal stability and optoelectronic properties.
• Polymer Modification: Acts as a monomer or grafting agent to incorporate halogenated benzoic acid units into specialty polymers, improving chemical resistance and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, multi-substituted arenes for research and scale-up.

Basic Information

Item	Detail
Product Name	3-Chloro-2,4,6-Trifluorobenzoic Acid
CAS No.	174312-95-9
Molecular Formula	C7H2ClF3O2
Molecular Weight	216.54 g/mol
Synonyms	2,4,6-Trifluoro-3-chlorobenzoic Acid; Benzoic acid, 3-chloro-2,4,6-trifluoro-; 3-Chloro-2,4,6-trifluorobenzenecarboxylic acid; 174312-95-9; 3-Chloro-2,4,6-trifluoro-benzoic acid; 3-Chloro-2,4,6-trifluorobenzoic acid (ACI); 3-Chloro-2,4,6-trifluorobenzoic acid, 97%
EINECS	Contact for details

Quality Control

Every batch of 3-Chloro-2,4,6-Trifluorobenzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your project requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.