Description

6-Trifluoromethoxychromone-2-Carboxylic Acid is a high-value fluorinated chromone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique trifluoromethoxy-substituted chromone scaffold makes it an essential building block for developing novel bioactive molecules with enhanced metabolic stability and membrane permeability. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing novel small-molecule drug candidates, particularly in oncology, inflammation, and CNS disorder research.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for improved bioactivity.
• Chemical Biology Probe: Serves as a core structure for designing fluorescent probes or activity-based protein profiling (ABPP) reagents to study enzyme function.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique optical or electronic properties.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploring new chemical spaces in medicinal chemistry.

Basic Information

Product Name	6-Trifluoromethoxychromone-2-Carboxylic Acid
CAS No.	174011-58-6
Molecular Formula	C₁₁H₅F₃O₅
Molecular Weight	274.15 g/mol
Synonyms	6-(Trifluoromethoxy)-2H-chromene-2-carboxylic acid; 6-(Trifluoromethoxy)chromone-2-carboxylic acid; 2-Carboxy-6-trifluoromethoxychromone; 6-Trifluoromethoxy-2-carboxychromone; 6-Trifluoromethoxy-2H-1-benzopyran-2-carboxylic acid; 174011-58-6; 6-Trifluoromethoxychromone-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 6-Trifluoromethoxychromone-2-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.