Description

Nepicastat CAS NO 173997-05-2 is a potent and selective inhibitor of dopamine β-hydroxylase (DBH), an enzyme crucial in the biosynthesis of norepinephrine. This targeted mechanism of action makes it a valuable research tool for investigating the adrenergic nervous system and its role in various physiological and pathological states. It is primarily utilized by pharmaceutical researchers and academic institutions in preclinical studies related to cardiovascular function, stress responses, and neuropsychiatric disorders.

Application

• Neuroscience Research: Used as a pharmacological tool to study the role of norepinephrine in brain function, behavior, and models of depression, anxiety, and addiction.
• Cardiovascular Research: Employed in preclinical models to investigate the effects of modulating sympathetic nervous system activity on blood pressure, heart failure, and arrhythmias.
• Pharmacological Profiling: Serves as a reference standard in assay development and high-throughput screening for identifying novel DBH inhibitors.
• Biochemical Studies: Utilized in enzymatic studies to understand the kinetics and inhibition mechanisms of dopamine β-hydroxylase.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental scientific investigations into catecholamine biology.

Basic Information

Product Name	Nepicastat
CAS No.	173997-05-2
Molecular Formula	C16H16N2O3S
Molecular Weight	316.38 g/mol
Synonyms	RS-25560-197; (R)-5-(Aminomethyl)-1-(6,8-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,3-dihydro-2H-imidazole-2-thione hydrochloride; Nepicastat hydrochloride; SYN-117; DBH Inhibitor
EINECS	Contact for details

Quality Control

Our Nepicastat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.