Description

Atrasentan CAS NO 173937-91-2 is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and manufacturers in the life sciences sector for investigating and developing novel therapeutic agents.

Application

• Pharmaceutical Research & Development (R&D): Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in drug discovery programs.
• Oncology Research: Investigated for its potential role in cancer therapy, particularly in targeting pathways associated with tumor growth and metastasis.
• Cardiovascular Disease Studies: Used in preclinical research to study endothelin receptor function in conditions like hypertension and pulmonary arterial hypertension.
• Biochemical Assay Development: Employed as a selective ligand in developing high-throughput screening assays and receptor binding studies.
• Metabolic Disorder Research: Explored for potential applications in diabetic nephropathy and other kidney-related disorders.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental pharmacological and physiological studies.

Basic Information

Product Name	Atrasentan
CAS No.	173937-91-2
Molecular Formula	C29H38N2O6S
Molecular Weight	542.69 g/mol
Synonyms	ABT-627; (+)-A-127722; (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid; Atrasentan Hydrate; ABT 627; A-127722
EINECS	Contact for details

Quality Control

Our Atrasentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, identification by spectroscopic methods (IR, NMR, MS), and determination of residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.