Description

Trans (2,3)-Dihydro Tetrabenazine is a high-purity synthetic intermediate and reference standard of significant pharmaceutical importance. This compound is a key derivative in the research and development of vesicular monoamine transporter 2 (VMAT2) inhibitors, which are critical for treating hyperkinetic movement disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) for analytical and synthetic purposes.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of tetrabenazine and related compounds via HPLC, LC-MS, and NMR.
• Active Pharmaceutical Ingredient (API) Intermediate: A crucial synthetic precursor in the manufacturing pathway for VMAT2 inhibitor drugs.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research for deuterated tetrabenazine (e.g., Deutetrabenazine).
• Biochemical Research: Serves as a tool compound in neuroscience research to study monoamine storage and release mechanisms.
• Impurity Profiling: Essential for identifying and controlling specified and unspecified impurities in tetrabenazine-based drug substances and products.
• Method Development & Validation: Supports the development and validation of stability-indicating analytical methods for regulatory filings.

Basic Information

Product Name	Trans (2,3)-Dihydro Tetrabenazine
CAS No.	171598-74-6
Molecular Formula	C19H27NO3
Molecular Weight	317.42 g/mol
Synonyms	(2R,3R,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol; (RRR)-Dihydrotetrabenazine; (+)-α-Dihydrotetrabenazine; (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol; Tetrabenazine Dihydro Derivative; trans-DHTBZ
EINECS	Contact for details

Quality Control

Our Trans (2,3)-Dihydro Tetrabenazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances and residual solvents, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.