Description

1-Hexadecanoyl-2-(p-Nitrophenoxysuccinoyl)-Sn-Glyceryl-3-Phosphorylcholine is a synthetic, chemically defined phospholipid derivative, specifically a lysophosphatidylcholine analog. This compound is of significant value as a critical biochemical reagent and a versatile building block for advanced lipid research and formulation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and specialty chemical manufacturers working on membrane biophysics, drug delivery systems, and enzyme kinetics studies.

Application

• Biochemical Research: As a substrate for phospholipase A2 (PLA2) enzyme activity assays, where the p-nitrophenoxysuccinoyl group acts as a chromogenic leaving group.
• Lipidomics & Analytical Standards: Used as a high-purity reference standard for mass spectrometry (MS) and chromatography to identify and quantify related lipid species in complex biological samples.
• Drug Delivery System Development: A key component in the design and study of liposomes, lipid nanoparticles (LNPs), and other advanced vesicular carriers for targeted therapeutic delivery.
• Membrane Biophysics Studies: Employed to investigate lipid-protein interactions, membrane fluidity, and the structural properties of artificial lipid bilayers.
• Enzyme Inhibitor Screening: Serves as a tool compound in high-throughput screening (HTS) campaigns to discover novel inhibitors of phospholipases.
• Specialty Chemical Synthesis: Acts as a sophisticated intermediate for the synthesis of more complex, functionalized phospholipids with tailored properties.

Basic Information

Product Name	1-Hexadecanoyl-2-(p-Nitrophenoxysuccinoyl)-Sn-Glyceryl-3-Phosphorylcholine
CAS No.	170569-87-6
Molecular Formula	C₃₆H₆₃N₂O₁₄P
Molecular Weight	778.87 g/mol
Synonyms	PNPS-LysoPC; 1-Palmitoyl-2-(4-nitrophenylsuccinyl)-sn-glycero-3-phosphocholine; p-Nitrophenylphosphorylcholine analog; PLA2 Substrate analog; 1-Hexadecanoyl-2-(4-nitrophenoxysuccinoyl)-sn-glycero-3-phosphocholine; LysoPC-PNPS; Chromogenic lysophosphatidylcholine; sn-Glycero-3-phosphocholine, 1-hexadecanoyl-2-[(4-nitrophenoxy)succinoyl]-
EINECS	Contact for details

Quality Control

Our 1-Hexadecanoyl-2-(p-Nitrophenoxysuccinoyl)-Sn-Glyceryl-3-Phosphorylcholine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere such as argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum matches theoretical molecular ion
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in chloroform, methanol, DMSO; partially soluble in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.