Description

4-(Trifluoromethyl)Thiazole-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block characterized by its trifluoromethyl-substituted thiazole core. This compound matters as a critical intermediate for synthesizing advanced molecules, where the thiazole ring provides structural diversity and the trifluoromethyl group enhances metabolic stability and lipophilicity. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by specialty chemical manufacturers for advanced material science applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in antiviral, anticancer, and anti-inflammatory research pipelines.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for constructing complex ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as semiconductors and light-emitting components.
• Fluorine Chemistry Studies: An important compound for investigating structure-activity relationships (SAR) in fluorine-containing molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke chemical production.

Basic Information

Product Name	4-(Trifluoromethyl)Thiazole-5-Carboxylic Acid
CAS No.	167548-89-2
Molecular Formula	C5H2F3NO2S
Molecular Weight	197.14 g/mol
Synonyms	5-Thiazolecarboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-1,3-thiazole-5-carboxylic acid; 4-Trifluoromethylthiazole-5-carboxylic acid; 4-(Trifluoromethyl)-5-thiazolecarboxylic acid; 4-Trifluoromethyl-5-carboxythiazole; 5-Carboxy-4-(trifluoromethyl)thiazole; TFMT-CA; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 4-(Trifluoromethyl)Thiazole-5-Carboxylic Acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under dry conditions to prevent product degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.