Description

Heptakis-o-(4-Sulfobutyl)-β-Cyclodextrin is a chemically modified, anionic cyclodextrin derivative designed for superior solubility and complexation capabilities. This compound is critical for enhancing the bioavailability and stability of poorly soluble active ingredients in pharmaceutical formulations. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for drug delivery, chiral separation, and solubility enhancement applications. Its unique sulfobutyl ether groups provide consistent performance in aqueous systems.

Application

• Pharmaceutical Solubilizing Agent: Used to significantly increase the aqueous solubility and dissolution rate of poorly water-soluble drugs for injectable and oral formulations.
• Chiral Selector in Capillary Electrophoresis (CE): Employed as a chiral additive in the buffer for the separation and analysis of enantiomers in drug development and quality control.
• Drug Delivery System Component: Serves as a functional excipient in the design of novel drug delivery systems, including nanoparticles and inclusion complexes, to improve drug stability and targeting.
• Protein Stabilization: Helps stabilize proteins and peptides in liquid formulations by preventing aggregation and surface adsorption.
• Analytical Chemistry Reagent: Used as a mobile phase additive in HPLC and UPLC methods to improve peak shape and separation of challenging analytes.
• Catalyst and Reaction Media Modifier: Can be utilized in synthetic chemistry to modify reaction environments and influence reaction pathways due to its host-guest complexation properties.

Basic Information

Product Name	Heptakis-o-(4-Sulfobutyl)-β-Cyclodextrin
CAS No.	165133-56-2
Molecular Formula	C56H98O56S7 (Approximate, degree of substitution may vary)
Molecular Weight	~ 2,200 g/mol (Average)
Synonyms	Sulfobutyl Ether β-Cyclodextrin, Sodium Salt; SBE-β-CD; Captisol® (commercial brand); Heptakis(6-O-sulfobutyl)-β-cyclodextrin; β-Cyclodextrin, sulfobutyl ethers, sodium salts; 4-Sulfobutyl ether-β-cyclodextrin; SBECD; Anionic β-cyclodextrin polymer
EINECS	Contact for details

Quality Control

Our Heptakis-o-(4-Sulfobutyl)-β-Cyclodextrin is manufactured under a quality management system. Each batch is tested to ensure it meets stringent specifications for identity, purity, and substitution degree, relevant for pharmaceutical development. Certificates of Analysis (COA) documenting key parameters are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Degree of Substitution (Avg.)	6.0 - 7.0
Water Content (KF)	≤ 10.0 %
Residue on Ignition (Sulfated Ash)	10.0 - 20.0 %
pH (10% solution)	5.0 - 7.5
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.