Description

(S)-(+)-Dbd-Py-Ncs CAS NO 163927-32-0 is a high-purity, chiral chemical building block featuring a reactive isothiocyanate (NCS) group. This compound is essential for researchers and manufacturers requiring enantiomerically pure intermediates for advanced synthesis. It is primarily utilized in the development of pharmaceuticals, agrochemicals, and specialized materials where stereochemical integrity is critical for efficacy and performance.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting neurological and metabolic disorders.
• Agrochemical Research: Used in developing enantiomerically pure herbicides, fungicides, and plant growth regulators with enhanced activity and selectivity.
• Ligand and Catalyst Synthesis: Serves as a versatile building block for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Fluorescent Probe Development: The Dbd (dibenzodiazepine) and pyridine moieties make it suitable for constructing advanced fluorescent labeling agents and molecular probes.
• Peptide and Protein Conjugation: The reactive isothiocyanate group enables efficient coupling to amines, useful for bioconjugation and antibody-drug conjugate (ADC) linker chemistry.
• Material Science: Employed in the research of chiral organic frameworks and advanced polymeric materials with specific optical properties.

Basic Information

Product Name	(S)-(+)-Dbd-Py-Ncs
CAS No.	163927-32-0
Molecular Formula	C₂₀H₁₃N₃OS
Molecular Weight	343.40 g/mol
Synonyms	(S)-(+)-2-(4-Isothiocyanatophenyl)-5,6-dihydrobenzo[h]quinazolin-10(11H)-one; (S)-Dbd-Py-NCS; (S)-enantiomer of Dbd-Py-Ncs; (S)-4-(10-Oxo-5,6-dihydrobenzo[h]quinazolin-2-yl)phenyl isothiocyanate; (+)-Dbd-Py-Ncs; DBD-Py-NCS (S-form); Chiral Dbd-Py isothiocyanate
EINECS	Contact for details

Quality Control

Our (S)-(+)-Dbd-Py-Ncs is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.