Description

(S)-(+)-Nbd-Py-Ncs is a chiral, enantiomerically pure chemical building block featuring both a nitrobenzoxadiazole (NBD) fluorophore and an isothiocyanate (NCS) reactive group. This compound matters for researchers and manufacturers requiring a highly specific, fluorescent labeling reagent for the selective modification of amines, particularly in the development of chiral probes and sensors. It is primarily needed by professionals in pharmaceutical research, analytical chemistry, and life sciences for applications in bio-conjugation, fluorescence microscopy, and the synthesis of advanced diagnostic materials.

Application

• Fluorescent Labeling of Biomolecules: Selective conjugation to primary amines in proteins, peptides, and antibodies for tracking and detection.
• Development of Chiral Fluorescent Probes: Synthesis of enantioselective sensors for analytical chemistry and diagnostic assays.
• Bio-conjugation and Bioconjugate Chemistry: Creating stable thiourea linkages for attaching fluorophores to targeting molecules.
• Cell Imaging and Microscopy: Preparation of fluorescent tags for cellular and subcellular imaging studies.
• Pharmaceutical Intermediate: Use in the research and development of novel therapeutic agents requiring chiral, fluorescent components.
• Material Science Research: Incorporation into smart polymers or surfaces for sensing applications.

Basic Information

Product Name	(S)-(+)-Nbd-Py-Ncs
CAS No.	163927-30-8
Molecular Formula	C₁₇H₁₀N₆O₄S
Molecular Weight	394.36 g/mol
Synonyms	(S)-4-(7-Nitro-2,1,3-benzoxadiazol-4-yl)-2-(isothiocyanatomethyl)pyrrolidine; (S)-(+)-NBD-Py-NCS; NBD-Py-NCS (S-enantiomer); 4-((S)-2-(Isothiocyanatomethyl)pyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole; (S)-NBD-APy-NCS; (S)-NBD-Aminopyrrolidine-NCS; NBD Fluorophore Isothiocyanate (S-form); Chiral NBD-NCS Reagent
EINECS	Contact for details

Quality Control

Our (S)-(+)-Nbd-Py-Ncs is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment to guarantee traceability and performance consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light should be avoided to maintain stability and performance. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.