Description

2'-O-(2-Methoxyethyl)-5-Methyluridine is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role in enhancing the stability and efficacy of oligonucleotide-based therapeutics. It is primarily utilized by research institutions and biotechnology companies focused on antisense technology, siRNA, and mRNA applications. The product is supplied to meet the stringent purity requirements of preclinical and process development stages.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key building block for constructing oligonucleotides with improved nuclease resistance and binding affinity.
• siRNA and miRNA Research: Used in the chemical modification of small interfering RNA (siRNA) and microRNA (miRNA) to enhance stability and pharmacokinetic properties.
• Therapeutic mRNA Development: Incorporated into modified mRNA sequences to reduce immunogenicity and increase translational efficiency for vaccine and protein replacement therapies.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of novel nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism and repair.
• Diagnostic Probe Development: Used in the design of labeled probes for genetic testing and molecular diagnostics.

Basic Information

Product Name	2'-O-(2-Methoxyethyl)-5-Methyluridine
CAS No.	163759-49-7
Molecular Formula	C13H20N2O7
Molecular Weight	316.31 g/mol
Synonyms	5-Methyl-2'-O-(2-methoxyethyl)uridine; 2'-MOE-5-Methyluridine; 2'-O-Methoxyethyl-5-methyluridine; 5-Methyl-2'-O-(2-methoxyethyl)uridine; 2'-O-(2-Methoxyethyl)-5-methyluridine; 2'-MOE-5-Me-Uridine; Uridine, 2'-O-(2-methoxyethyl)-5-methyl-
EINECS	Contact for details

Quality Control

Our 2'-O-(2-Methoxyethyl)-5-Methyluridine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research and development applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.