Description

Benzamil Hydrochloride CAS NO 161804-20-2 is a potent and selective inhibitor of the epithelial sodium channel (ENaC). This compound is a critical research tool for studying ion transport mechanisms and related physiological pathways. It is primarily utilized by pharmaceutical researchers, academic institutions, and R&D laboratories focused on cardiovascular, renal, and pulmonary systems.

Application

• Biomedical Research: A key pharmacological agent for investigating the role of ENaC in hypertension, cystic fibrosis, and other channelopathies.
• Mechanistic Studies: Used in in vitro and ex vivo models to elucidate sodium reabsorption and fluid balance mechanisms.
• Drug Discovery: Serves as a reference standard and lead compound in the development of novel diuretics and ENaC-targeting therapeutics.
• Academic & Clinical Research: Essential for foundational studies in physiology and pharmacology within university and hospital research settings.

Basic Information

Product Name	Benzamil Hydrochloride
CAS No.	161804-20-2
Molecular Formula	C14H16ClN7O • HCl
Molecular Weight	378.69 g/mol
Synonyms	Benzamil HCl; N-Benzyl-amiloride hydrochloride; 3,5-Diamino-N-(benzylamino-carbonyl)-6-chloropyrazinecarboxamide hydrochloride; Benzamil; ENaC Inhibitor Benzamil; Amiloride benzyl analogue hydrochloride
EINECS	Contact for details

Quality Control

Our Benzamil Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.