Description

3-Bromo-4-Fluorocinnamic Acid is a high-purity halogenated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and fluorine substituents, makes it an invaluable intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used as a precursor in the development of new herbicides, fungicides, and plant growth regulators, leveraging the bioactivity of the halogenated aromatic system.
• Liquid Crystal & OLED Materials: Serves as a building block for creating advanced organic electronic materials due to its ability to modify conjugation and intermolecular interactions.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Studies: Used as a model compound in research exploring the effects of fluorine substitution on reaction kinetics, metabolic stability, and binding affinity.
• Peptide Mimetics & Bioconjugation: The carboxylic acid functionality allows for coupling to amines, making it useful for creating peptide analogs or for bioconjugation applications.

Basic Information

Product Name	3-Bromo-4-Fluorocinnamic Acid
CAS No.	160434-49-1
Molecular Formula	C9H6BrFO2
Molecular Weight	245.05 g/mol
Synonyms	(E)-3-(3-Bromo-4-fluorophenyl)acrylic acid; 3-Bromo-4-fluorocinnamic acid; trans-3-(3-Bromo-4-fluorophenyl)-2-propenoic acid; 2-Propenoic acid, 3-(3-bromo-4-fluorophenyl)-, (2E)-; 3-Bromo-4-fluoro-trans-cinnamic acid; (E)-3-(3-Bromo-4-fluorophenyl)prop-2-enoic acid; 3-Bromo-4-fluorobenzeneacrylic acid
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluorocinnamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements of research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.