Description

L-745,870 Trihydrochloride is a high-purity, small molecule compound of significant interest in pharmaceutical research and development. This compound serves as a potent and selective dopamine D4 receptor antagonist, making it a critical tool for neuropharmacological studies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the investigation of central nervous system disorders, receptor pharmacology, and drug discovery programs.

Application

• Pharmacological Research: Used as a selective dopamine D4 receptor antagonist in vitro and in vivo studies to understand receptor function and signaling pathways.
• Neuroscience Drug Discovery: Serves as a key reference compound or lead structure in the development of novel therapeutics for CNS conditions such as schizophrenia, Parkinson's disease, and addiction.
• Biochemical Assay Development: Employed as a standard or control in high-throughput screening (HTS) assays to identify and characterize new receptor ligands.
• Academic & Institutional Research: Utilized in university and hospital laboratories for fundamental research into dopaminergic systems and their role in behavior and disease.
• Preclinical Studies: Applied in animal model studies to evaluate the efficacy and mechanism of action of potential neuropsychiatric drugs.

Basic Information

Product Name	L-745,870 Trihydrochloride
CAS No.	158985-00-3
Molecular Formula	C19H21N3O2 • 3HCl
Molecular Weight	439.77 g/mol (free base: 323.39 g/mol)
Synonyms	L-745870; L745870; 3-[(4-(4-Chlorophenyl)piperazin-1-yl)methyl]-1H-pyrrolo[2,3-b]pyridine trihydrochloride; (S)-3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine trihydrochloride; PNU-101387G; PNU 101387G; Dopamine D4 receptor antagonist L-745,870
EINECS	Contact for details

Quality Control

Our L-745,870 Trihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.