Description

Dihydrexidine Hydrochloride is a high-purity, synthetically produced chemical compound of significant interest in advanced pharmaceutical research and development. This compound serves as a potent and selective full agonist for dopamine D1 receptors, making it a critical tool for neurological studies and drug discovery programs. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in neuroscience, psychopharmacology, and the development of novel central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: As a key pharmacological tool for studying dopamine D1 receptor signaling pathways, neuronal function, and behavior.
• Drug Discovery & Development: Used in high-throughput screening (HTS) and lead optimization for potential therapies targeting Parkinson's disease, cognitive disorders, and schizophrenia.
• In Vitro & Ex Vivo Studies: Employed in cell-based assays and tissue preparations to investigate receptor activation, downstream effects, and cellular responses.
• Preclinical Animal Studies: Utilized in rodent models to evaluate the efficacy, pharmacokinetics, and behavioral effects of dopaminergic compounds.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Reagent: Used in the preparation of buffers and solutions for specialized biochemical and pharmacological experiments.

Basic Information

Product Name	Dihydrexidine Hydrochloride
CAS No.	158704-02-0
Molecular Formula	C18H21NO2·HCl
Molecular Weight	311.83 g/mol (Free base: 275.36 g/mol)
Synonyms	(±)-Dihydrexidine Hydrochloride; trans-10,11-Dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine Hydrochloride; A-77636 Hydrochloride; DHX HCl; D1 Dopamine Receptor Agonist; 5,6,6a,7,8,12b-Hexahydrobenzo[a]phenanthridine-10,11-diol Hydrochloride
EINECS	Contact for details

Quality Control

Our Dihydrexidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for identity (IR, HPLC), assay (HPLC), and related substances. We adhere to relevant industry standards for research chemicals to support your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.