Description

1-Palmitoyl-2-Cholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid derivative, also known as a cholesteryl hemisuccinate (CHEMS) conjugate, designed for advanced research and formulation applications. This compound is critical for creating stable, pH-sensitive liposomal delivery systems that enable the targeted release of therapeutic agents. It is primarily needed by pharmaceutical researchers, drug delivery scientists, and manufacturers in the liposome and nanomedicine sectors for developing next-generation cancer therapies, gene delivery vectors, and diagnostic imaging agents.

Application

• pH-Sensitive Liposome Formulation: A key component for constructing liposomes that destabilize and release their cargo in the acidic microenvironment of tumors or within cellular endosomes.
• Targeted Drug Delivery Systems: Used in the development of novel nanocarriers for chemotherapeutic agents, reducing systemic toxicity and improving therapeutic efficacy.
• Gene and siRNA Delivery: Facilitates the encapsulation and intracellular delivery of nucleic acids for gene therapy and RNA interference applications.
• Diagnostic Imaging: Serves as a building block for contrast agent carriers in medical imaging techniques like MRI and fluorescence imaging.
• Membrane Biophysics Research: Employed in model membrane studies to investigate lipid-lipid interactions, membrane fusion, and stability under varying pH conditions.
• Cosmetic & Dermal Delivery: Potential use in advanced cosmetic formulations for the controlled release of active ingredients into the skin.

Basic Information

Product Name	1-Palmitoyl-2-Cholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine
CAS No.	155401-40-4
Molecular Formula	C57H102NO9P
Molecular Weight	968.39 g/mol
Synonyms	CHEMS-PC; Cholesteryl Hemisuccinate Phosphatidylcholine; 1-Palmitoyl-2-(cholesterylhemisuccinoyl)-sn-glycero-3-phosphocholine; pH-sensitive lipid; 16:0 CHEMS PC; Palmitoyl-CHEMS-PC; Cholesteryl Hemisuccinoyl Phospholipid; DSPC-CHEMS (related analog)
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Cholesterylhemisuccinoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive) and easily oxidized; therefore, vials should be equilibrated to room temperature in a desiccator before opening to prevent condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0%
Phase Transition Temperature (DSC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.