Description

Tezampanel is a potent and selective non-competitive antagonist of the AMPA/kainate glutamate receptors. This compound is a critical research tool for investigating the role of glutamate-mediated neurotransmission in neurological pathways. It is primarily utilized by pharmaceutical researchers and neuroscientists in the development and study of novel therapeutics for conditions such as neuropathic pain, epilepsy, and neurodegenerative diseases.

Application

• Neuroscience Research: A key pharmacological agent for studying AMPA and kainate receptor function in synaptic transmission and plasticity.
• Drug Discovery: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical research for central nervous system (CNS) disorders.
• Pain Research: Investigated in models of chronic and neuropathic pain due to its mechanism of action on glutamate receptors involved in pain signaling.
• Epilepsy Studies: Employed in research exploring glutamate receptor antagonists as potential anticonvulsant agents.
• Biochemical Assays: Serves as a standard in receptor binding assays and functional studies to characterize new chemical entities.
• Academic & Institutional Research: Essential for university and hospital laboratories focused on neuropharmacology and molecular neuroscience.

Basic Information

Product Name	Tezampanel
CAS No.	154652-83-2
Molecular Formula	C₁₅H₁₇N₅O₃
Molecular Weight	315.33 g/mol
Synonyms	NGX424; LY293558; (3S,4aR,6R,8aR)-6-[2-(1H-Tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid; Tezampanel hydrochloride; LY-293558; AMPA/Kainate receptor antagonist
EINECS	Contact for details

Quality Control

Our Tezampanel is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis to ensure it meets high-grade research standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product at 2-8°C. The container should be kept in a well-ventilated area and handled with appropriate personal protective equipment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm
Assay	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.