Description

4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside-6-O-sulfate potassium salt is a specialized fluorogenic substrate designed for the sensitive detection and quantification of specific sulfatase enzyme activity. This compound matters because it enables precise biochemical research and diagnostic applications by releasing a highly fluorescent product upon enzymatic cleavage. It is primarily needed by researchers and manufacturers in the life sciences, pharmaceutical development, and clinical diagnostics sectors for studying lysosomal storage disorders and other enzyme-related pathologies. The product is supplied as a high-purity biochemical reagent to ensure reliable and reproducible experimental results.

Application

• Enzyme Activity Assays: Fluorogenic substrate for the specific detection and kinetic analysis of N-acetylglucosamine-6-sulfatase (G6S) and related sulfatase enzymes.
• Diagnostic Research: Key reagent in the development of diagnostic kits for lysosomal storage disorders such as Mucopolysaccharidosis III D (Sanfilippo D syndrome).
• Biochemical Research: Used in high-throughput screening (HTS) platforms to identify potential therapeutic compounds or enzyme inhibitors.
• Cell Biology Studies: Employed to measure sulfatase activity within live cells or cell lysates for functional genomics and disease modeling.
• Quality Control in Biomanufacturing: Acts as a process control tool to monitor enzyme purity and activity during the production of biologic therapeutics.
• Academic Research: Fundamental tool for universities and research institutes studying carbohydrate metabolism, enzyme mechanisms, and genetic diseases.

Basic Information

Product Name	4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside-6-O-sulfate potassium salt
CAS No.	154639-35-7
Molecular Formula	C18H20KNO12S
Molecular Weight	513.51 g/mol
Synonyms	4-MU-α-GlcNAc-6-S; 4-Methylumbelliferyl α-GlcNAc-6-sulfate potassium salt; 4-Methylumbelliferyl N-acetyl-α-D-glucosaminide-6-sulfate K+ salt; Fluorogenic G6S substrate; 4-MU-α-GlcNAc-6-SO4 K salt; 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside 6-sulfate potassium salt; 6-Sulfate-4-methylumbelliferyl N-acetyl-α-D-glucosaminide potassium salt
EINECS	Contact for details

Quality Control

Our 4-Methylumbelliferyl 2-acetamido-2-deoxy-α-D-glucopyranoside-6-O-sulfate potassium salt is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity verification and spectroscopic confirmation of structure. Certificates of Analysis (COA) detailing purity, identity, and performance in standard enzyme assays are provided with every shipment. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Enzymatic Activity	Suitable for use as a substrate
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.