Description

3-Chloro-2,4-Difluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of halogen substituents, which enables precise molecular modifications for developing novel compounds with targeted properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for creating active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Employed to introduce halogenated benzoate groups into polymer chains, altering thermal stability, solubility, and other material properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to construct complex, multi-substituted aromatic systems.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new fluorination chemistry and structure-activity relationships.

Basic Information

Product Name	3-Chloro-2,4-Difluorobenzoic Acid
CAS No.	154257-75-7
Molecular Formula	C7H3ClF2O2
Molecular Weight	192.55 g/mol
Synonyms	2,4-Difluoro-3-chlorobenzoic Acid; Benzoic acid, 3-chloro-2,4-difluoro-; 3-Chloro-2,4-difluorobenzoic acid; 154257-75-7; 2,4-Difluoro-3-chlorobenzoic acid; 3-Chloro-2,4-difluoro-benzoic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-2,4-Difluorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We support compliance with global regulatory frameworks, and custom purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider using desiccants to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.