Description

Trecovirsen CAS NO 153021-75-1 is a synthetic phosphorothioate oligonucleotide designed as an antisense therapeutic agent. This compound is of significant interest for its targeted mechanism of action in inhibiting viral replication. It is primarily utilized by pharmaceutical researchers and manufacturers in the development of antiviral therapies, particularly for conditions such as cytomegalovirus (CMV) retinitis in immunocompromised patients.

Application

• Antiviral Drug Development: Core active pharmaceutical ingredient (API) for research and production of antisense-based antiviral medications.
• Ophthalmic Formulations: Key component in the formulation of intravitreal injections for treating CMV retinitis.
• Biomedical Research: Used as a tool compound in virology and molecular biology to study antisense mechanisms and viral gene expression.
• Preclinical & Clinical Studies: Serves as the investigational material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Pharmaceutical Intermediates: May be used in the synthesis of more complex oligonucleotide conjugates or prodrugs.

Basic Information

Product Name	Trecovirsen
CAS No.	153021-75-1
Molecular Formula	C204H247N63O114P20S20
Molecular Weight	Contact for details
Synonyms	GEM® 132; ISIS 2922; Fomivirsen sodium; (P-Thio)(CGC CCA TCT TCT TCT TCC G); Antisense oligonucleotide ISIS 2922; 5'-d(CpGpCpCpCpApTpCpTpTpCpTpTpCpTpTpCpC)-3', P-thioate; Novivir
EINECS	Contact for details

Quality Control

Our Trecovirsen is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications. Certificates of Analysis (COA) detailing purity, impurity profile, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.