Description

Bexlosteride CAS NO 152323-03-0 is a potent and selective nonsteroidal inhibitor of the enzyme 5-α-reductase type 2. This compound is of significant value in pharmaceutical research and development, particularly for investigating androgen-dependent conditions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of treatments for benign prostatic hyperplasia (BPH), androgenetic alopecia, and other disorders influenced by dihydrotestosterone (DHT) pathways.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Mechanistic Biochemical Research: Used as a critical tool compound in in vitro and in vivo studies to elucidate the role of 5-α-reductase type 2 in steroid metabolism.
• Preclinical Drug Development: Employed in the screening and profiling of new chemical entities targeting androgen-related pathways for conditions like BPH and prostate cancer.
• Academic Research: Facilitates fundamental biological studies in endocrinology, urology, and dermatology within university and institutional labs.
• Active Pharmaceutical Ingredient (API) Intermediate: Acts as a key synthetic intermediate in the production pathway for finished dosage forms under GMP conditions.

Basic Information

Product Name	Bexlosteride
CAS No.	152323-03-0
Molecular Formula	C₂₃H₂₆N₂O₂
Molecular Weight	362.47 g/mol
Synonyms	Bexlosteride; 4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide; PNU 157706; PNU-157706; 4-Aza-5α-androst-1-en-3-one, 17β-(aminocarbonyl)-4-methyl-; (5α,17β)-4-Methyl-3-oxo-4-azaandrost-1-ene-17-carboxamide
EINECS	Contact for details

Quality Control

Our Bexlosteride is manufactured and tested to meet stringent quality standards suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality management systems to ensure batch-to-batch consistency and traceability. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.