Description

Aprinocarsen is a synthetic oligonucleotide-based pharmaceutical compound with the CAS registry number 151879-73-1. This compound is significant for its targeted mechanism of action, designed to inhibit specific gene expression at the molecular level. It is primarily utilized in advanced pharmaceutical research and development, particularly in the fields of oncology and gene therapy, where precise biological modulation is required.

Application

• Pharmaceutical Research & Development: As a key active pharmaceutical ingredient (API) or intermediate in the development of novel therapeutic agents.
• Oncology Studies: Investigation into its potential as an antisense oligonucleotide for targeting cancer-related genes and pathways.
• Preclinical & Clinical Trials: Sourcing material for toxicology, pharmacokinetic, and efficacy studies in various disease models.
• Biochemical Research: Used as a tool compound to study gene function, mRNA inhibition, and cellular signaling mechanisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Aprinocarsen
CAS No.	151879-73-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ISIS 3521; LY900003; CGP 64128A; Aprinocarsen sodium; Afinitak; 20-mer phosphorothioate oligonucleotide; Antisense oligonucleotide targeting protein kinase C-alpha
EINECS	Contact for details

Quality Control

Our Aprinocarsen is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling using advanced techniques like HPLC and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications and supporting its use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under dry, inert conditions at a controlled room temperature (typically 15-25°C). For long-term stability, consider storage at -20°C in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0% Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.