Description

Benzoic Acid, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)-, (R)- (9Ci) is a high-value chiral building block characterized by a trifluoromethyl-substituted ethanol side chain on the benzoic acid core. This compound matters for its role in synthesizing advanced pharmaceutical intermediates and agrochemicals, where the trifluoromethyl group and specific stereochemistry impart desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the trifluoromethyl group enhances lipophilicity and bioactivity.
• Liquid Crystal Materials: Serves as a precursor for fluorine-containing liquid crystal compounds used in display technologies.
• Asymmetric Catalysis Research: Employed as a substrate or ligand precursor in the development of new chiral catalysts and synthetic methodologies.
• Fluorine Chemistry Studies: A valuable compound for investigating structure-activity relationships (SAR) in medicinal and agrochemical chemistry due to its defined stereochemistry and fluorine content.
• Advanced Material Monomer: Can be utilized to synthesize specialized polymers with unique optical or surface properties.

Basic Information

Item	Detail
Product Name	Benzoic Acid, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)-, (R)- (9Ci)
CAS No.	150821-42-4
Molecular Formula	C9H7F3O3
Molecular Weight	220.15 g/mol
Synonyms	(R)-4-(2,2,2-Trifluoro-1-hydroxyethyl)benzoic acid; (R)-α-(Trifluoromethyl)-4-hydroxybenzeneacetic acid; (R)-4-(1-Hydroxy-2,2,2-trifluoroethyl)benzoic acid; (R)-TFEBA; p-[(R)-1-Hydroxy-2,2,2-trifluoroethyl]benzoic acid; (R)-Trifluoromethylmandelic acid benzoic acid derivative; (R)-Configuration isomer of CAS 150821-42-4
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-(2,2,2-Trifluoro-1-Hydroxyethyl)-, (R)- (9Ci) is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% (R)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.