Description

3-Chloro-4,5-Difluorobenzoic Acid is a high-purity fluorinated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique substitution pattern, which allows for precise structural modifications in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

This versatile intermediate is primarily used in the synthesis of complex molecules. Key application areas include:

• Pharmaceutical Intermediates: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated and chlorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and chloro substituents contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Polymer Chemistry: Can be incorporated as a monomer or modifier to create specialty polymers with specific thermal or chemical resistance properties.
• Organic Synthesis & Research: A valuable reagent in academic and industrial R&D for constructing complex aromatic structures and exploring structure-activity relationships.

Basic Information

Product Name	3-Chloro-4,5-Difluorobenzoic Acid
CAS No.	150444-95-4
Molecular Formula	C7H3ClF2O2
Molecular Weight	192.55 g/mol
Synonyms	Benzoic acid, 3-chloro-4,5-difluoro-; 4,5-Difluoro-3-chlorobenzoic acid; 3-Chloro-4,5-difluorobenzoic acid; 150444-95-4; 3-Chloro-4,5-difluoro-benzoic acid; 3-Chloro-4,5-difluorobenzoic acid (ACI); SCHEMBL11827527
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,5-Difluorobenzoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.