Description

1-Palmitoyl-2-Linoleoylphosphatidylfluorouridine is a synthetic, fluorinated phospholipid-nucleoside conjugate designed for advanced research and development. This specialized compound is engineered to combine the membrane-targeting properties of phospholipids with the bioactivity of a modified nucleoside, enabling precise delivery and action. It is a critical reagent for pharmaceutical researchers, particularly in the fields of targeted drug delivery systems, lipid nanoparticle (LNP) formulation, and the study of nucleic acid metabolism and signaling pathways.

Application

• Lipid Nanoparticle (LNP) Research: A key functional component for formulating and optimizing next-generation LNPs for the delivery of mRNA, siRNA, and other nucleic acid therapeutics.
• Targeted Drug Delivery Systems: Serves as a building block for creating phospholipid conjugates that enhance the cellular uptake and specificity of pharmaceutical agents.
• Biochemical & Cell Biology Research: Used as a probe or substrate to study enzyme kinetics, membrane biophysics, and intracellular signaling pathways involving phospholipids and nucleotides.
• Pharmaceutical Intermediate: Acts as a sophisticated synthetic intermediate in the development of novel antiviral or anticancer prodrugs.
• Diagnostic Agent Development: Potential use in the synthesis of contrast agents or molecular probes for imaging technologies due to its incorporable fluorine atom.

Basic Information

Product Name	1-Palmitoyl-2-Linoleoylphosphatidylfluorouridine
CAS No.	148763-98-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PLPFU; 1-Palmitoyl-2-linoleoyl-sn-glycero-3-phospho-5-fluorouridine; Fluorouridine phosphatidylcholine derivative; 5-Fluorouridine phospholipid conjugate; 1-Palmitoyl-2-linoleoylphosphatidyl-5-fluorouridine; sn-Glycero-3-phospho-5-fluorouridine 1-palmitoyl-2-linoleoyl ester; Phospholipid-fluorouridine hybrid molecule
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Linoleoylphosphatidylfluorouridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and a Certificate of Analysis (COA) with key parameters including assay (HPLC), related substances, and confirmation of structure (NMR, MS). Our quality systems support development from research to pre-clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to ensure long-term stability. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.