Description

Thioperamide Maleate Salt CAS NO 148440-81-7 is a high-purity, pharmacologically active compound widely recognized as a potent and selective histamine H3 receptor antagonist. This specificity makes it an invaluable research tool for studying the role of the histaminergic system in the central nervous system. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in neuroscience, neuropharmacology, and drug discovery programs.

Application

• Neuroscience Research: A critical tool for investigating the physiological and pathological roles of histamine H3 receptors in the brain.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for CNS-targeted therapeutics.
• Academic & Preclinical Studies: Employed in *in vitro* and *in vivo* models to explore potential treatments for cognitive disorders, sleep-wake cycle dysregulation, and obesity.
• Biochemical Assay Development: Serves as a key component in developing and validating receptor binding and functional assays.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	Thioperamide Maleate Salt
CAS No.	148440-81-7
Molecular Formula	C15H21N3OS • C4H4O4
Molecular Weight	407.48 g/mol
Synonyms	Thioperamide Maleate; Thioperamide hydrogen maleate; N-Cyclohexyl-4-(imidazol-4-yl)piperidine-1-carbothioamide maleate salt; 1-[(4(5)-Imidazolyl)methyl]piperidine-4-cyclohexylaminothiocarbonyl Maleate; H3 Receptor Antagonist Thioperamide Maleate; Impromidine analog (H3 antagonist); [1-[4(5)-Imidazolylmethyl]piperidyl]-N-cyclohexylthiourea maleate
EINECS	Contact for details

Quality Control

Our Thioperamide Maleate Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR spectroscopy, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.