Description

Gts-21 is a synthetic, small-molecule compound of significant interest in pharmacological research. It serves as a selective agonist for the α7 subtype of nicotinic acetylcholine receptors (α7 nAChR), a key target for modulating cognitive and neuroinflammatory pathways. This product is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on neuroscience, cognitive disorders, and novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for studying the role of α7 nAChRs in synaptic plasticity, learning, and memory.
• Drug Discovery & Preclinical Studies: Used as a reference standard and active pharmaceutical ingredient (API) in the development of treatments for cognitive deficits associated with conditions like Alzheimer's disease and schizophrenia.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and in vitro binding assays to identify and characterize new modulators of the α7 nAChR.
• Neuroinflammation Research: Investigated for its potential anti-inflammatory effects via the cholinergic anti-inflammatory pathway mediated by α7 receptors.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in neuropharmacology and receptor biology.

Basic Information

Product Name	Gts-21
CAS No.	148372-04-7
Molecular Formula	C₁₈H₂₁N₃O₂
Molecular Weight	311.38 g/mol
Synonyms	DMXBA; 3-(2,4-Dimethoxybenzylidene)-anabaseine; GTS 21; GTS-21 dihydrochloride (salt form); TC-1698; 3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine; ABT-418 analog; α7 nAChR agonist
EINECS	Contact for details

Quality Control

Our Gts-21 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.