Description

Dbd-Ncs CAS NO 147611-81-2 is a specialized chemical intermediate, primarily known as a reactive labeling reagent containing an N-hydroxysuccinimide (NHS) ester group. This compound matters for its ability to form stable amide bonds with primary amines, making it a critical tool for the site-specific modification and conjugation of biomolecules. It is essential for researchers and manufacturers in the fields of bioconjugation, proteomics, and diagnostic assay development, where precise chemical tagging is required.

Application

• Bioconjugation Reagent: For covalent labeling of antibodies, proteins, peptides, and oligonucleotides with fluorescent dyes or other probes.
• Proteomics Research: Used in activity-based protein profiling (ABPP) and other chemical proteomics strategies to label and identify enzyme active sites.
• Diagnostic Kit Manufacturing: A key component in the synthesis of enzyme-linked or fluorescently-labeled detection reagents for immunoassays.
• Drug Discovery: Employed in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic constructs.
• Material Science: Surface functionalization of nanoparticles, polymers, and biosensors to introduce specific reactive groups.
• Chemical Biology Tool: For studying protein function, interactions, and localization within complex biological systems.

Basic Information

Item	Detail
Product Name	Dbd-Ncs
CAS No.	147611-81-2
Molecular Formula	C23H19N3O6S
Molecular Weight	465.48 g/mol
Synonyms	4-(N,N-Dimethylaminosulfonyl)-7-(2-Aminoethylamino)-2,1,3-Benzoxadiazole N-Hydroxysuccinimide Ester; DBD-ED-NHS; 7-(2-Aminoethylamino)-4-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole NHS Ester; DBD-NHS; DBD Fluorophore NHS Ester; DBD-ED-NHS Ester; 147611-81-2; DBD Dye NHS Ester
EINECS	Contact for details

Quality Control

Our Dbd-Ncs is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive biochemical applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange powder or crystalline solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.