Description

Trifluoromethyl Penicillin V is a chemically modified derivative of the classic penicillin V antibiotic, distinguished by the strategic introduction of a trifluoromethyl group. This structural modification is designed to enhance key pharmacological properties, such as metabolic stability and membrane permeability, making it a valuable intermediate in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and research organizations focused on developing next-generation antibacterial agents and exploring novel β-lactam structures.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel β-lactam antibiotics with potentially improved efficacy and resistance profiles.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to investigate the impact of fluorine substitution on antibiotic potency and pharmacokinetics.
• Antibacterial Agent Development: Acts as a precursor for developing new penicillin derivatives targeting resistant bacterial strains.
• Biochemical Research: Employed in studies exploring the mechanism of action and binding affinity of modified penicillins to penicillin-binding proteins (PBPs).
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation related to novel penicillin compounds.

Basic Information

Product Name	Trifluoromethyl Penicillin V
CAS No.	146554-88-3
Molecular Formula	C17H19F3N2O5S
Molecular Weight	420.41 g/mol
Synonyms	(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(2-phenoxy-4-(trifluoromethyl)acetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-(Trifluoromethyl)phenoxymethylpenicillin; Penicillin V Trifluoromethyl Derivative; 6-[D-α-(4-Trifluoromethylphenoxy)acetamido]penicillanic acid; α-(4-Trifluoromethylphenoxy)methylpenicillin
EINECS	Contact for details

Quality Control

Our Trifluoromethyl Penicillin V is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, purity, and impurity profile. We adhere to relevant industry standards for pharmaceutical intermediates, and custom purity grades can be supported upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Unknown Impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.