Description

2-Hydroxy-6-(Trifluoromethyl)Benzoic Acid is a versatile trifluoromethylated salicylic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group with a strongly electron-withdrawing trifluoromethyl substituent, makes it a valuable precursor for creating compounds with enhanced biological activity and physicochemical properties. This high-purity intermediate is essential for research and development in the pharmaceutical and agrochemical sectors, where it is used to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in developing anti-inflammatory, antimicrobial, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves efficacy and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal complexation.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modulate electronic properties.
• Chemical Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	2-Hydroxy-6-(Trifluoromethyl)Benzoic Acid
CAS No.	144433-66-9
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	6-(Trifluoromethyl)salicylic acid; 2-Hydroxy-6-(trifluoromethyl)benzoic acid; Salicylic acid, 6-(trifluoromethyl)-; 6-Trifluoromethylsalicylic Acid; α-Hydroxy-α-(trifluoromethyl)-o-toluic acid (obsolete); 2-Carboxy-3-(trifluoromethyl)phenol
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.