Description

Ethyl 2-Bromo-4,5-Difluorobenzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters because it provides a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research, where the bromo and difluoro substituents offer precise points for further functionalization. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluorophenyl motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve compound activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated aromatic cores used in electronic materials, contributing to improved performance in display technologies.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification of molecular libraries.
• Fluorine Chemistry Exploration: A valuable reagent for studying the effects of fluorine substitution on chemical reactivity and physical properties in medicinal chemistry programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions.

Basic Information

Product Name	Ethyl 2-Bromo-4,5-Difluorobenzoate
CAS No.	144267-97-0
Molecular Formula	C9H7BrF2O2
Molecular Weight	265.05 g/mol
Synonyms	2-Bromo-4,5-difluorobenzoic Acid Ethyl Ester; Benzoic acid, 2-bromo-4,5-difluoro-, ethyl ester; Ethyl 2-bromo-4,5-difluorobenzoate; Ethyl α-bromo-4,5-difluorobenzoate; 4,5-Difluoro-2-bromobenzoic Acid Ethyl Ester; Ethyl 4,5-Difluoro-2-bromobenzoate; 144267-97-0; Ethyl 2-Bromo-4,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-4,5-Difluorobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For advanced applications, we offer material produced under ISO 9001 guidelines and can support development with analytical method validation and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Handle and store in accordance with good laboratory practices, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.