Description

n-(3,5-Dinitrobenzoyl)-D-Proline is a high-purity chiral derivatizing agent and analytical reagent. This compound is specifically designed for the resolution and analysis of enantiomers, offering critical support for quality control and research in stereochemistry. It is an essential tool for pharmaceutical R&D, academic research, and quality assurance laboratories requiring precise chiral separation and identification.

Application

• As a chiral derivatizing agent (CDA) for the HPLC and LC-MS analysis of enantiomeric purity.
• For the preparation of diastereomeric derivatives to facilitate the separation and quantification of optical isomers.
• In method development for the quality control of chiral active pharmaceutical ingredients (APIs) and intermediates.
• As a key reagent in academic and industrial research focused on asymmetric synthesis and stereochemistry.
• For use in validating analytical methods in compliance with GMP and ICH guidelines.
• Supporting process development and optimization in the manufacture of enantiomerically pure drugs.

Basic Information

Product Name	n-(3,5-Dinitrobenzoyl)-D-Proline
CAS No.	143492-63-1
Molecular Formula	C₁₂H₁₁N₃O₇
Molecular Weight	309.23 g/mol
Synonyms	(2R)-1-[(3,5-Dinitrophenyl)carbonyl]pyrrolidine-2-carboxylic acid; D-Proline, N-(3,5-dinitrobenzoyl)-; DNBP; 3,5-Dinitrobenzoyl-D-proline; (R)-1-(3,5-Dinitrobenzoyl)pyrrolidine-2-carboxylic acid; D-(-)-N-(3,5-Dinitrobenzoyl)proline; Chiral Derivatizing Reagent DNBP-Pro; Marfey's reagent derivative
EINECS	Contact for details

Quality Control

Our n-(3,5-Dinitrobenzoyl)-D-Proline is manufactured under strict quality systems to ensure high chemical and chiral purity, essential for reliable analytical results. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess. We adhere to rigorous internal standards to guarantee batch-to-batch consistency for your critical research and quality control applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.