Description

Boc-Phe-n-Carboxyanhydride is a specialized N-carboxyanhydride (NCA) derivative used as a key building block in the controlled synthesis of polypeptides and peptide-polymer conjugates. This compound matters because it enables the precise, ring-opening polymerization of N-substituted glycine derivatives (peptoids) and other amino acid analogs, offering superior control over molecular weight and polymer architecture. It is essential for researchers and manufacturers in pharmaceutical development, advanced biomaterials, and specialty polymer chemistry who require high-purity intermediates for creating novel therapeutic agents and functional materials.

Application

• Peptoid Synthesis: Primary monomer for the controlled ring-opening polymerization (ROP) of N-substituted glycines to create peptoid polymers with defined sequences and chain lengths.
• Bioconjugation & Hybrid Materials: Building block for synthesizing peptide-polymer hybrids and bioconjugates used in drug delivery systems and diagnostic agents.
• Pharmaceutical Intermediates: Critical starting material in the research and development of novel peptide-based active pharmaceutical ingredients (APIs).
• Biomaterials Engineering: Used to fabricate functional coatings, hydrogels, and scaffolds for tissue engineering and medical device applications.
• Combinatorial Chemistry: Enables the rapid generation of diverse peptoid libraries for high-throughput screening in drug discovery.
• Academic & Industrial R&D: Serves as a fundamental reagent for studies in polymer chemistry, supramolecular assembly, and biomimetic material design.

Basic Information

Product Name	Boc-Phe-n-Carboxyanhydride
CAS No.	142955-51-9
Molecular Formula	C₁₅H₁₇NO₅
Molecular Weight	291.30 g/mol
Synonyms	Boc-Phe-NCA; (Boc-Phenylalanine) N-Carboxyanhydride; N-(tert-Butoxycarbonyl)-L-phenylalanine N-carboxyanhydride; 1-[(2-Methyl-2-propanyl)oxycarbonyl]-L-phenylalanine 2,5-dioxo-1,3-oxazolidine; Boc-L-Phenylalanine NCA; tert-Butoxycarbonylphenylalanine N-carboxyanhydride; Nα-Boc-L-phenylalanine N-carboxyanhydride; Boc-Phenylalanine-NCA
EINECS	Contact for details

Quality Control

Our Boc-Phe-n-Carboxyanhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive polymerization and pharmaceutical applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions, preferably in a dry inert atmosphere, to maintain stability and prevent premature polymerization or hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.