Description

Polymyxin B Heptapeptide is a defined, cyclic peptide fragment derived from the polymyxin B antibiotic structure. This compound is of significant value in pharmaceutical research and development, particularly for studying the structure-activity relationships of polymyxin-class antibiotics and their mechanisms of action against Gram-negative bacteria. It serves as a critical intermediate and reference standard for scientists in antimicrobial research, medicinal chemistry, and peptide synthesis. The product is supplied under stringent quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Antimicrobial Research & Development: Used as a key intermediate or reference standard for studying the mechanism of action, resistance, and structure-activity relationships (SAR) of polymyxin antibiotics.
• Medicinal Chemistry & Drug Design: Serves as a building block or template for the synthesis of novel peptide-based antimicrobial agents with potentially improved efficacy and reduced toxicity.
• Biochemical & Microbiological Assays: Employed as a precise tool in in-vitro assays to investigate bacterial membrane interactions and the role of specific peptide regions in antimicrobial activity.
• Pharmaceutical Reference Standard: Acts as a high-purity certified reference material (CRM) for quality control and analytical method development in antibiotic manufacturing.
• Academic & Institutional Research: Essential for fundamental research in microbiology, pharmacology, and peptide science within universities and research institutes.

Basic Information

Product Name	Polymyxin B Heptapeptide
CAS No.	142563-40-4
Molecular Formula	C36H62N10O10
Molecular Weight	794.95 g/mol
Synonyms	Polymyxin B1 Heptapeptide; Polymyxin B Nonapeptide Truncated Fragment; Dab-Thr-Dab-Dab-Dab-Dab-Dab; Cyclo[Dab-Dab-Dab-Dab-Dab-Thr-Dab]; 6-Amino-1-[[(2S,3S,6R)-6-[[(2S)-2,6-diamino-1-oxohexyl]amino]-1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-3-methyl-2-oxopiperidin-3-yl]amino]-4-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]amino]-1,4-dioxohexan-2-aminium
EINECS	Contact for details

Quality Control

Our Polymyxin B Heptapeptide is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.