Description

4-Chloro-7-Chlorosulfonyl-2,1,3-Benzoxadiazole is a highly reactive and versatile chemical intermediate, primarily valued for its role as a key derivatization reagent in analytical chemistry. Its core value proposition lies in enabling the sensitive detection and quantification of target analytes, particularly amines and amino acids, through fluorescence or UV detection. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and environmental monitoring sectors who require high-purity, reliable reagents for advanced analytical methods.

Application

• Derivatization Reagent for HPLC/LC-MS Analysis: Used to tag primary and secondary amines, amino acids, and other nucleophiles to enhance their detectability and chromatographic performance.
• Pharmaceutical Impurity Profiling: Critical in the analysis and quantification of trace-level genotoxic impurities (GTIs) and other reactive intermediates in Active Pharmaceutical Ingredients (APIs).
• Proteomics and Biomarker Research: Employed in labeling peptides and proteins for fluorescence-based detection in gel electrophoresis or liquid chromatography applications.
• Environmental Analysis: Applied in the derivatization and subsequent detection of aliphatic and aromatic amines in water, soil, and air samples.
• Food Safety Testing: Utilized in methods for detecting biogenic amines (e.g., histamine, putrescine) in food and beverage products.
• Synthetic Intermediate: Serves as a building block for the synthesis of more complex benzoxadiazole-based dyes, sensors, and pharmaceutical compounds.

Basic Information

Product Name	4-Chloro-7-Chlorosulfonyl-2,1,3-Benzoxadiazole
CAS No.	142246-48-8
Molecular Formula	C6H2Cl2N2O3S
Molecular Weight	265.06 g/mol
Synonyms	4-Chloro-7-chlorosulfonylbenzofurazan; 4-Chloro-7-chlorosulfonyl-2,1,3-benzoxadiazole; 4-Chloro-7-sulfonyl chloride benzofurazan; 4-Chloro-7-sulfonyl chloride-2,1,3-benzoxadiazole; 4-Chloro-7-chlorosulfonylbenz-2,1,3-oxadiazole; 4-Cl-7-SO2Cl-BD; BD-Cl; 7-Chlorosulfonyl-4-chloro-2,1,3-benzoxadiazole
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Chlorosulfonyl-2,1,3-Benzoxadiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent decomposition. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.