Description

Rna "A" Phosphoramidite CAS NO 141913-04-4 is a high-purity, nucleoside phosphoramidite monomer specifically designed for the solid-phase synthesis of RNA oligonucleotides. This compound is a critical building block for creating precise RNA sequences, enabling research and development in advanced therapeutic and diagnostic fields. It is essential for biotechnology, pharmaceutical, and academic laboratories engaged in antisense technology, siRNA development, and structural biology studies.

Application

• Solid-Phase RNA Synthesis: Primary monomer for the automated chemical synthesis of research-grade and therapeutic RNA oligonucleotides.
• Therapeutic RNA Development: Key raw material in the production of siRNA (small interfering RNA), miRNA, and antisense oligonucleotides for drug discovery.
• Diagnostic Probe Manufacture: Used to synthesize labeled RNA probes for applications in genomics, in situ hybridization, and microarray analysis.
• Structural Biology Studies: Enables the production of custom RNA sequences for NMR and X-ray crystallography to study RNA structure and function.
• CRISPR Research: Component in the synthesis of guide RNAs (gRNAs) for gene editing and functional genomics applications.
• Aptamer Development: Building block for creating RNA aptamers used in biosensors, targeted therapeutics, and molecular recognition.

Basic Information

Product Name	Rna "A" Phosphoramidite
CAS No.	141913-04-4
Molecular Formula	C47H55N6O8P
Molecular Weight	863.0 g/mol
Synonyms	Adenosine Phosphoramidite; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-benzoyladenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine-3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); RNA Adenosine Phosphoramidite; rA Phosphoramidite; DMT-rA(Bz)-CE Phosphoramidite; 2'-TBDMS rA Phosphoramidite
EINECS	Contact for details

Quality Control

Our Rna "A" Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot undergoes comprehensive analytical testing including HPLC purity analysis, NMR structural confirmation, and 31P NMR for phosphorous assay. Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and reduced coupling efficiency.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.