Description

8-Oxodeoxyguanosine Triphosphate (CAS NO 139307-94-1) is a modified nucleoside triphosphate analog critical for advanced biochemical and molecular biology research. This compound serves as a vital tool for studying oxidative DNA damage, repair mechanisms, and mutagenesis. It is essential for researchers and manufacturers in the fields of genomics, diagnostic assay development, and pharmaceutical research, particularly for investigating the biological impact of reactive oxygen species.

Application

• Oxidative DNA Damage Studies: Used as a substrate to investigate the mechanisms and consequences of 8-oxoguanine lesions in DNA.
• Enzyme Kinetics & Repair Pathway Analysis: Essential for studying the activity of DNA repair enzymes like OGG1 and other glycosylases.
• In Vitro Mutagenesis Assays: Incorporated during PCR or enzymatic synthesis to study transversion mutations (G to T) caused by oxidative stress.
• Diagnostic Kit Development: A key component in kits designed to detect and quantify oxidative stress biomarkers.
• Biochemical Probe Synthesis: Used in the enzymatic synthesis of oligonucleotide probes containing site-specific oxidative damage for structural and functional studies.
• Pharmaceutical Screening: Employed in high-throughput screens to identify potential therapeutics that modulate DNA repair pathways.

Basic Information

Product Name	8-Oxodeoxyguanosine Triphosphate
CAS No.	139307-94-1
Molecular Formula	C10H16N5O14P3
Molecular Weight	523.16 g/mol
Synonyms	8-Oxo-dGTP; 8-Hydroxy-2'-deoxyguanosine-5'-triphosphate; 8-Oxo-7,8-dihydro-2'-deoxyguanosine-5'-triphosphate; 8-OH-dGTP; OxoGTP; 8-Oxo-2'-deoxyguanosine-5'-triphosphate; 8-Oxoguanine triphosphate; 8-Oxo-7,8-dihydro-2'-deoxyguanosine triphosphate
EINECS	Contact for details

Quality Control

Our 8-Oxodeoxyguanosine Triphosphate is manufactured under stringent conditions to ensure the highest standards of purity and stability for research applications. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, identity confirmation (UV/IR), and quantification of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results and ensuring traceability and reproducibility for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/UV)	Conforms
Purity (HPLC)	≥ 95%
Related Substances (HPLC)	≤ 5.0% total
Water Content (KF)	≤ 5.0%
Biological Activity	Suitable for enzyme incorporation assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.