Description

Methyl 2-Bromomethyl-5-Fluoro-Benzoate is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional reactivity, featuring both a bromomethyl group for nucleophilic substitution and an ester moiety for hydrolysis or transesterification, making it a versatile precursor. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a fluorinated benzyl moiety.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Material Science Precursor: Serves as a starting material for creating specialized ligands for catalysis or fluorinated monomers for advanced polymers.
• Cross-Coupling Reactions: The bromomethyl group can participate in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form carbon-carbon bonds.
• Derivatization Agent: Utilized in medicinal chemistry for the functionalization of lead compounds to explore structure-activity relationships (SAR).
• Fluorine-Containing Compound Library Synthesis: An essential building block for combinatorial chemistry and the generation of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Methyl 2-Bromomethyl-5-Fluoro-Benzoate
CAS No.	138786-65-9
Molecular Formula	C9H8BrFO2
Molecular Weight	247.06 g/mol
Synonyms	Methyl 5-Fluoro-2-(bromomethyl)benzoate; 2-Bromomethyl-5-fluorobenzoic Acid Methyl Ester; 5-Fluoro-2-(bromomethyl)benzoic Acid Methyl Ester; Benzoic acid, 2-(bromomethyl)-5-fluoro-, methyl ester; Methyl (2-bromomethyl-5-fluorophenyl)carboxylate
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromomethyl-5-Fluoro-Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.